An Electrophoretic Examination of a Urinary Mucoprotein Which Reacts with Various Viruses
نویسندگان
چکیده
A mucoprotein isolated from human urine and possessing the capacity to react with a number of viruses is electrophoretically homogeneous at pH 6.8 and 8.6. After treatment with influenza virus and elimination of its biological activity, the substance remains homogeneous and its electrophoretic mobility is decreased by approximately 20 per cent.
منابع مشابه
Ultracentrifugation studies of a urinary mucoprotein which reacts with various viruses.
The isolation from normal human urine of a highly viscous, electrophoretically homogeneous mucoprotein has been described previously (l-3). This substance combines with influenza, mumps, and Newcastle disease viruses and is altered enzymatically by them (l-6). This alteration in the mucoprotein results in loss of the capacity to combine with viruses and in reduction of the electrophoretic mobil...
متن کاملAn Electrophoretic Examination of a Urinary
A number of the properties of a mucoprotein which has been isolated from human urine and obtained in a highly purified state are described in the preceding paper (1). This substance is capable of reacting with certain viruses and several features of the interaction with influenza viruses are those of an enzymesubstrate system. The mucoprotein is altered by active influenza viruses; one evidence...
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A mucoprotein, present in normal human urine, has been isolated and obtained in a state of a high degree of purity. A number of the biological, chemical, and physicochemical properties of the substance have been studied. From the results obtained in the present investigation and those reported in succeeding papers (34, 35) it appears that the mucoprotein has a high molecular weight, i.e., of th...
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The fibrous urinary mucoprotein of Tamm and Horsfall, which is a temporary inhibitor of the hemagglutination reaction of the myxoviruses, exists in normal human urine in two molecular forms, one a tetramer of the other (1). The smaller form, of molecular weight 7 X 106, length 6 X lo3 A, and width 40 A, can be dissociated further by transverse cleaving into half molecules (2) and into quarter m...
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Investigations by some of us (l-3) have been concerned with the demonstration by electrophoresis of mucoproteins in normal and pathological sera. It was found that at least three electrophoretic components were present in crude mucoprotein fractions. More recently, the isolation in electrophoretically homogeneous form of the major mucoprotein component of normal human plasma has been described,...
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عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 95 شماره
صفحات -
تاریخ انتشار 1952